Free Antibacterial Agents Chemistry Mode of Action Mechanisms of Resistance and Clinical Applications
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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic†approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry. Origins and Evolution of Antibiotic Resistance FIG 1 History of antibiotic discovery and concomitant development of antibiotic resistance The dark ages the preantibiotic era; primordial Treatment of Infections Associated with Surgical Implants Review Article Current Concepts Treatment of Infections Associated with Surgical Implants Rabih O Darouiche MD N Engl J Med 2004; 350:1422-1429 April 1 2004 Antibiotics in the clinical pipeline in 2013 The Journal 1 Division of Chemistry and Structural Biology Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia Correspondence Novel Strategies for the Treatment of Pseudomonas Stefanie Wagner received a diploma in biology from the Technical University of Darmstadt (Germany) and a PhD in infection biology from the Biocenter of the What the Experts Say About Colloidal Silver! What the experts say about colloidal silver and other silver-based antimicrobials [While the FDA uses their legal prerogative to assert that colloidal silver has Artemisinin Resistance in Plasmodium falciparum Malaria - NEJM Original Article Artemisinin Resistance in Plasmodium falciparum Malaria Arjen M Dondorp MD Franois Nosten MD Poravuth Yi MD Debashish Das MD Applications : BioTek Applications The following resources are available to illustrate product specific capabilities and common applications for BioTek microplate instrumentation Antimicrobial activity of metals: mechanisms molecular Metals have been used as antimicrobial agents since antiquity but throughout most of history their modes of action have remained unclear Recent studies indicate Chitosan - Wikipedia Chitosan has a rich history of being researched for applications in agriculture and horticulture dating back to the 1980s By 1989 chitosan salt solutions were Design Synthesis and Evaluation of Bifunctional Supramolecular and Material Chemistry Lab School of Physical Sciences Jawaharlal Nehru University New Mehrauli Road 110067 New Delhi India School of Life
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